Roy came out during the third quarter of the Blazers' 120-108 victory over the Milwaukee Bucks on Wednesday night. He had an MRI Thursday morning which confirmed the strain.
The two-time All-Star leads the Blazers with 23.4 points and 5.1 assists per game.
The injury-depleted Blazers have had to lean on Roy, who is in his fourth NBA season.
Jerryd Bayless was tapped to start in Roy's place Friday night against the Magic.
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