Przybilla hurt his leg during Portland's 85-81 victory at Dallas on Tuesday night. He went up for a rebound and came down awkwardly with 3:12 left in the first quarter.
Przybilla had surgery on Thursday. He averaged 4.1 points, 7.9 rebounds and 1.4 blocks in 30 games this season.
The Blazers have been beset by so many injuries this season that the NBA granted the team an exemption to carry 16 players on its roster.